Optimasi Formula Tablet Dispersible Kalium Diklofenak dengan Bahan Pengikat Avicel PH-101 dan Bahan Penghancur Amprotab

Authors

  • Irmawati Hidayah Jurusan Farmasi, Fakultas Ilmu-ilmu Kesehatan, Universitas Jenderal Soedirman, Indonesia
  • Vitis Vini Fera Ratna Utami Jurusan Farmasi, Fakultas Ilmu-ilmu Kesehatan, Universitas Jenderal Soedirman, Indonesia
  • Dhadhang Wahyu Kurniawan Universitas Jenderal Soedirman

Keywords:

Tablet dispersible, Kalium Diklofenak, Simplex Lattice Design, avicel PH-101, amprotab

Abstract

Tablet dispersibel merupakan salah satu bentuk sediaan tablet yang digunakan dengan cara mendispersikan tablet terlebih dahulu. Kalium Diklofenak merupakan salah satu obat analgesik kuat yang sering digunakan dalam terapi analgeseik pada osteoarthritis dan Rhematoid Artrhitis. Kalium diklofenak dibuat dalam sediaan tablet dispersible dimaksudkan untuk mempercepat onset. Kombinasi Avicel PH-101 sebagai bahan pengisi dengan amprotab sebagai bahan disintegrasi dalam pembuatan tablet dispersible Kalium Diklofenak diharapkan dapat mempercepat waktu terdispersi tablet. Tujuan Penelitian ini untuk mengetahui proporsi optimum campuran Avicel PH 101 dan amprotab dalam formulasi tablet dispersible Kalium diklofenak dengan metode Simplex Lattice Design (SLD). Formula tablet dirancang berdasarkan metode SLD dengan eksipien Avicel PH-101 (A) dan Amprotab (B) yaitu : F1(100%A), F2(100%B), F3 (50%A:50%B), F4 (75%A:25%B), F5 (25%A:75%B). Tablet dispersibel kalium diklofenak dibuat dengan metode kempa langsung. Kemudian diuji sifat fisiknya yang meliputi keseragaman bobot, keseragaman ukuran, kekerasan, kerapuhan, waktu disintegrasi, waktu terdispersi, waktu terbasahi, dan penetapan kadar. Berdasarkan hasil penelitian diketahui bahwa campuran Avicel PH 101 – Amprotab dapat mempengaruhi karakteristik fisik tablet dengan meningkatkan variasi keseragaman bobot, meningkatkan kekerasan, memperlama waktu terdispersi dan memperlama waktu hancur tablet dispersibel kalium diklofenak. Berdasar perhitungan respon total, formula optimum diperoleh pada campuran 10% Avicel PH 101 dan 90% Amprotab. Perhitungan tentang formula optimum didasarkan pada perhitungan nilai respon total yang tertinggi.

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Published

2024-06-30

How to Cite

Hidayah, I., Utami, V. V. F. R., & Kurniawan, D. W. (2024). Optimasi Formula Tablet Dispersible Kalium Diklofenak dengan Bahan Pengikat Avicel PH-101 dan Bahan Penghancur Amprotab . Jurnal Apoteker Indonesia, 1(3), 66–73. Retrieved from https://journal.talentainsan.com/index.php/jai/article/view/18

Issue

Vol. 1 No. 3 (2024): Jurnal Apoteker Indonesia Juni 2024

Section

Articles

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Copyright (c) 2024 Irmawati Hidayah, Vitis Vini Fera Ratna Utami, Dhadhang Wahyu Kurniawan

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