Nano Thermosensitive Hydrogels Curcumin in Drug Delivery Systems in Breast Cancer Therapy: Systematic Literature Review

Azis Ikhsanudin; Salma Kumala Dewi; Dwi Kartika  Indriani; Ardian Tirto; Mutiara Az-Zahra; Dina Ariyana Siagian; Nur Iqlima Alifatunnisa

Authors

Azis Ikhsanudin universitas ahmad dahlan
Salma Kumala Dewi
Dwi Kartika Indriani Universitas Ahmad Dahlan
Ardian Tirto Universitas Ahmad Dahlan
Mutiara Az-Zahra Universitas Ahmad Dahlan
Dina Ariyana Siagian Universitas Ahmad Dahlan
Nur Iqlima Alifatunnisa Universitas Ahmad Dahlan

Keywords:

curcumin; thermosensitve; hydrogel; drug delivery; cancer

Abstract

Cancer chemotherapy's enormous side effects drive the development of new medicines derived from plants. Curcumin has pharmacological activity as an anti-cancer. Oral bioavailability, low solubility, and ease of degradation complicate its clinical application. Curcumin has now been widely developed in the form of nanoparticles. Nanoparticles are usually formed in the form of polymers as drug carriers. The drug delivery system in breast cancer therapy with nano thermosensitive hydrogels methods has developed significantly due to the influence of the availability of various polymers that have characteristics affected by temperature changes. Drug release from thermosensitive gel preparations has advantages over conventional intravenous drug release. This study aims to assess the effectiveness of nano-thermosensitive hydrogels loaded with curcumin in the delivery of breast cancer drugs. The methods used are Systematic Literature Review (SLR) and bibliometric analysis. Research results show that curcumin in nano thermosensitive hydrogels can improve the bioavailability and efficacy of breast cancer therapy. This study concludes that curcumin formulated in nano thermosensitive hydrogels offers significant potential as an alternative therapy for breast cancer, although further research is needed to verify its safety and effectiveness in cancer therapy.

References

Adepu, S., Ramakrishna, S., 2021. Controlled Drug Delivery Systems: Current Status and Future Directions. Molecules 26.

Arnold, M., Morgan, E., Rumgay, H., Mafra, A., Singh, D., Laversanne, M., Vignat, J., Gralow, J.R., Cardoso, F., Siesling, S., Soerjomataram, I., 2022. Current and future burden of breast cancer: Global statistics for 2020 and 2040. Breast 66, 15–23.

Cao, D., Zhang, X., Akabar, M.D., Luo, Y., Wu, H., Ke, X., Ci, T., 2019. Liposomal doxorubicin loaded PLGA-PEG-PLGA based thermogel for sustained local drug delivery for the treatment of breast cancer. Artif. cells, nanomedicine, Biotechnol. 47, 181–191.

Chatterjee, S., Hui, P.C.-L., Kan, C.-W., 2018. Thermoresponsive Hydrogels and Their Biomedical Applications: Special Insight into Their Applications in Textile Based Transdermal Therapy. Polymers (Basel). 10.

Correa, S., Grosskopf, A.K., Lopez Hernandez, H., Chan, D., Yu, A.C., Stapleton, L.M., Appel, E.A., 2021. Translational Applications of Hydrogels. Chem. Rev. 121, 11385–11457.

Damyanov CA, Maslev IK, Pavlov VS. 2018. Conventional treatment of cancer realities and problems. Ann. Complement. Altern. Med. 1(1),1–9

Fan, J., Pung, E., Lin, Y., Wang, Q., 2022. Recent development of hydrogen sulfide-releasing biomaterials as novel therapies: a narrative review. Biomater. Transl.

Gupta, R., Xie, H., 2018. Nanoparticles in Daily Life: Applications, Toxicity and Regulations. J. Environ. Pathol. Toxicol. Oncol. Off. organ Int. Soc. Environ. Toxicol. Cancer 37, 209– 230.

Howaili, F., 2021. Stimuli-Responsive, Plasmonic Nanogel for Dual Delivery of Curcumin and Photothermal Therapy for Cancer Treatment. Front. Chem. 8.

Huang, M., Zhai, B.-T., Fan, Y., Sun, J., Shi, Y.-J., Zhang, X.-F., Zou, J.-B., Wang, J.-W., Guo, D.- Y., 2023. Targeted Drug Delivery Systems for Curcumin in Breast Cancer Therapy. Int. J. Nanomedicine 18, 4275–4311.

Karami, M.H., 2023. Novel chitosan/γ- alumina/carbon quantum dot hydrogel nanocarrier for targeted drug delivery. Int. J. Biol. Macromol. 251.

Kasi, P.D., Tamilselvam, R., Skalicka-Woźniak, K., Nabavi, S.F., Daglia, M., Bishayee, A., Pazoki- toroudi, H., Nabavi, S.M., 2016. Molecular targets of curcumin for cancer therapy: an updated review. Tumor Biol. 37, 13017–13028.

Kharat, M., Du, Z., Zhang, G., McClements, D.J., 2017. Physical and Chemical Stability of Curcumin in Aqueous Solutions and Emulsions: Impact of pH, Temperature, and Molecular Environment. J. Agric. Food Chem. 65, 1525–1532.

Nagahama, K., Utsumi, T., Kumano, T., Maekawa, S., Oyama, N., Kawakami, J., 2016. Discovery of a new function of curcumin which enhances its anticancer therapeutic potency. Sci. Rep. 6, 30962.

Pourmadadi, M., 2023. pH-responsive polyacrylic acid (PAA)-carboxymethyl cellulose (CMC) hydrogel incorporating halloysite nanotubes (HNT) for controlled curcumin delivery. Ind. Crops Prod. 197.

Sauter, E.R., 2020. Cancer prevention and treatment using combination therapy with natural compounds. Expert Rev. Clin. Pharmacol. 13, 265–285.

Senapati S, Mahanta AK, Kumar S, Maiti P., 2018. Controlled drug delivery vehicles for cancer treatment and their performance. Signal Transduct. Target. Ther. 3(1), 7

Trayes, K.P., Cokenakes, S.E.H., 2021. Breast Cancer Treatment. Am. Fam. Physician 104, 171–178.

Triandini, E., Jayanatha, S., Indrawan, A., Werla Putra, G., Iswara, B., 2019. Metode Systematic Literature Review untuk Identifikasi Platform dan Metode Pengembangan Sistem Informasi di Indonesia. Indones. J. Inf. Syst. 1, 63.

Urošević, M., Nikolić, L., Gajić, I., Nikolić, V., Dinić, A., Miljković, V., 2022. Curcumin: Biological Activities and Modern Pharmaceutical Forms. Antibiot. (Basel, Switzerland) 11.

Yu, C., Yang, B., Najafi, M., 2021. Targeting of cancer cell death mechanisms by curcumin: Implications to cancer therapy. Basic Clin. Pharmacol. Toxicol. 129, 397–415.